Selected Publications

Soares-Cunha C, Domingues AV, Correia R, Coimbra B, Gaspar N, Vasconcelos NAP, Pinto L, Sousa N, Rodrigues AJ (2021): Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports

Kataja EL, Rodrigues AJ, Scheinin N, Nolvi S, Korja R, Häikiö T, Ekholm E, Sousa N, Karlsson L, Karlsson H (2021): Prenatal glucocorticoid-exposed infants do not show an age-typical fear bias at 8 months of age – Preliminary findings from the FinnBrain Birth Cohort Study. Frontiers in Psychology

Coimbra B, Domingues AV, Soares-Cunha C, Correia R, Pinto L, Sousa N, Rodrigues AJ (2021): Laterodorsal tegmentum-Ventral Tegmental Area projections encode positive reinforcement signals. Journal of Neuroscience Research

Gaspar R, Soares-Cunha C, Domingues AV, Coimbra B, Baptista FI, Pinto L, Ambrósio AF, Rodrigues AJ*, Gomes CA* (2021): Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia. Neurobiol Stress

Domingues AV, Pereira IM, Vilaça-Faria H, Salgado AJ, Rodrigues AJ, Teixeira FG. (2020) Glial cells in Parkinson´s disease: protective or deleterious? Cell Mol Life Sci.

Ventura-Silva AP, Borges S, Sousa N, Rodrigues AJ*, Pêgo JM*. (2020) Amygdalar corticotropin-releasing factor mediates stress-induced anxiety. Brain Research

Coimbra B, Soares-Cunha C, Vasconcelos NAP, Domingues AV, Borges S, Sousa N*, Rodrigues AJ* (2019): Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nat Commun

Soares-Cunha C, de Vasconcelos NAP, Coimbra B, Domingues AV, Silva JM, Loureiro-Campos E, Gaspar R, Sotiropoulos I, Sousa N*, Rodrigues AJ* (2019): Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Mol Psychiatry

Duarte JM, Gaspar R, Caetano L, Patricio P, Soares-Cunha C, Mateus-Pinheiro A, Alves ND, Santos AR, Ferreira SG, Sardinha V, Oliveira JF, Fontes-Ribeiro C, Sousa N, Cunha RA, Ambrosio AF, Pinto L, Rodrigues AJ, Gomes CA* (2019): Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats. Glia

Soares-Cunha C, Coimbra B, Domingues AV, Vasconcelos N, Sousa N, Rodrigues AJ* (2018): Nucleus Accumbens Microcircuit Underlying D2-MSN-Driven Increase in Motivation. eNeuro

Soares-Cunha C, Coimbra B, Borges S, Domingues AV, Silva D, Sousa N, Rodrigues AJ* (2018): Mild Prenatal Stress Causes Emotional and Brain Structural Modifications in Rats of Both Sexes. Front Behav Neurosci

Coimbra B, Soares-Cunha C, Borges S, Vasconcelos NA, Sousa N, Rodrigues AJ* (2017): Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits. eLife

Soares-Cunha C, Coimbra B, David-Pereira A, Borges S, Pinto L, Costa P, Sousa N*, Rodrigues AJ* (2016): Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. Nat Commun

Soares-Cunha C, Coimbra B, Sousa N, Rodrigues AJ* (2016): Reappraising striatal D1- and D2-neurons in reward and aversion. Neurosci Biobehav Rev 68: 370–386.

Soares-Cunha C, Coimbra B, Borges S, Carvalho MM, Sousa N*, Rodrigues AJ* (2014): The motivational drive to natural rewards is modulated by prenatal glucocorticoid exposure. Transl Psychiatry

Borges S, Coimbra B, Soares-Cunha C, Ventura-Silva AP, Pinto L, Carvalho MM, Pego J-M, Sousa N*, Rodrigues AJ* (2013): Glucocorticoid programing of the mesopontine cholinergic system. Front Endocrinol

Borges S, Coimbra B, Soares-Cunha C, Miguel Pêgo J, Sousa N*, Rodrigues AJ* (2013): Dopaminergic modulation of affective and social deficits induced by prenatal glucocorticoid exposure. Neuropsychopharmacology

Ventura-Silva AP, Pego JM, Sousa JC, Marques AR, Rodrigues AJ, Marques F, Cerqueira JJ, Almeida OFX, Sousa N (2012): Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode. Eur J Neurosci

Rodrigues AJ, Leao P, Pego JM, Cardona D, Carvalho MM, Oliveira M, Costa BM, Carvalho AF, Morgado P, Araujo D, Palha JA, Almeida OFX, Sousa N (2012): Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids. Mol Psychiatry

Oliveira M, Rodrigues AJ, Leao P, Cardona D, Pego JM, Sousa N (2012): The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: implications for fear and anxiety responses. Psychopharmacology

Rodrigues AJ, Leão P, Carvalho M, Almeida OFX, Sousa N (2011): Potential programming of dopaminergic circuits by early life stress. Psychopharmacology

Oliveira M, Leao P, Rodrigues AJ, Pego J-M, Cerqueira J-J, Sousa N (2011): Programming effects of antenatal corticosteroids exposure in male sexual behavior. J Sex Med

Other publications

Patricio P et al. (2021) Cell Cycle Regulation of Hippocampal Progenitor Cells in Experimental Models of Depression and after Treatment with Fluoxetine. Int. J. Mol. Sci

Silveiro-Rosa et al. (2021) Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity. Cell Proliferation

Loureiro-Campos E et al. Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods. eLife

Mateus-Pinheiro et al. (2021): Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits. Molecular Psychiatry

Ferreira M, Francisco S, Soares AR, Nobre A, Pinheiro M, Reis A, Neto S, Rodrigues AJ, Sousa N, Moura G, Santos MA (2021): Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues. Aging

Castanho T, Santos NC, Meleiro-Neves C, Neto S, Moura GR, Santos MA, Cruz AR, Cunha O, Castro Rodrigues A, Rodrigues AJ, Sousa N (2021): Association of positive and negative life events with cognitive performance and psychological status in late life: a cross-sectional study in Northern Portugal. Aging Brain

Viitaniemi et al. (2021): Hair Cortisol Concentrations Are Associated with Dental Anxiety during Pregnancy. Dentistry Journal

Santos J, Proença MF, Rodrigues AJ, Patrício P, Domingues HS (2020) Recent advances on the synthesis of the antidepressant Paroxetine. Curr Med Chem

Patrício P, Mateus-Pinheiro A, Alves ND, Morais M, Rodrigues AJ, Bessa JM, Sousa N, Pinto L (2020) miR-409 and miR-411 Modulation in the Adult Brain of a Rat Model of Depression and After Fluoxetine Treatment. Front Behav Neurosci

Lotfi N, Fontenele AJ, Feliciano T, Aguiar LAA, de Vasconcelos NAP, Soares-Cunha C, Coimbra B, Rodrigues AJ, Sousa N, Copelli M, Carelli PV. (2020) Signatures of brain criticality unveiled by maximum entropy analysis across cortical states. Phys Rev E

Aatsinki AK, Keskitalo A, Laitinen V, Munukka E, Uusitupa HM, Lahti L, Kortesluoma S, Mustonen P, Rodrigues AJ, Coimbra B, Huovinen P, Karlsson H, Karlsson L (2020) Maternal prenatal psychological distress and hair cortisol levels associate with infant fecal microbiota composition at 2.5 months of age. Psychoneuroendocrinology

Kajanoja J, Karukivi M, Mustonen P, Scheinin NM, Kortesluoma S, Rodrigues AJ, Karlsson H, Karlsson L. (2020) Alexithymic Traits and Hair Cortisol Concentrations in Pregnant Women. Front Psychiatry

Duarte JM, Gaspar R, Caetano L, Patricio P, Soares-Cunha C, Mateus-Pinheiro A, Alves ND, Santos AR, Ferreira SG, Sardinha V, Oliveira JF, Fontes-Ribeiro C, Sousa N, Cunha RA, Ambrosio AF, Pinto L, Rodrigues AJ, Gomes CA* (2019): Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats. Glia

Fontenele AJ, de Vasconcelos NAP, Feliciano T, Aguiar LAA, Soares-Cunha C, Coimbra B, Dalla Porta L, Ribeiro S, Rodrigues AJ, Sousa N, Carelli PV, Copelli M (2019): Criticality between Cortical States. Physical Rev Letters

Mustonen P, Karlsson L, Kataja E-L, Scheinin NM, Kortesluoma S, Coimbra B, Rodrigues AJ, Sousa N, Karlsson H (2019): Maternal prenatal hair cortisol is associated with prenatal depressive symptom trajectories. Psychoneuroendocrinology

Guimaraes MR, Soares AR, Cunha AM, Esteves M, Borges S, Magalhaes R, Moreira PS, Rodrigues AJ, Sousa N, Almeida A, Leite-Almeida H (2019): Evidence for lack of direct causality between pain and affective disturbances in a rat peripheral neuropathy model. Genes Brain Behav

Vieira N, Bessa C, Rodrigues AJ, Marques P, Chan F-Y, de Carvalho AX, Correia-Neves M, Sousa N (2018): Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans. Cell Mol Life Sci

Torres DB, Lopes A, Rodrigues AJ, Cerqueira JJ, Sousa N, Gontijo JAR, Boer PA (2018): Anxiety-like behavior and structural changes of the bed nucleus of the stria terminalis (BNST) in gestational protein-restricted male offspring. J Dev Orig Health Dis

Soares AR, Esteves M, Moreira PS, Cunha AM, Guimaraes MR, Carvalho MM, Raposo-Lima C, Morgado P, Carvalho AF, Coimbra B, Melo A, Rodrigues AJ, Salgado AJ, Pego JM, Cerqueira JJ, Costa P, Sousa N, Almeida A, Leite-Almeida H (2018): Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats. Sci Reports

Mustonen P, Karlsson L, Scheinin NM, Kortesluoma S, Coimbra B, Rodrigues AJ, Karlsson H (2018): Hair cortisol concentration (HCC) as a measure for prenatal psychological distress – A systematic review. Psychoneuroendocrinology

de Vasconcelos NAP, Soares-Cunha C, Rodrigues AJ, Ribeiro S, Sousa N (2017): Coupled variability in primary sensory areas and the hippocampus during spontaneous activity. Sci Rep

Teixeira FG, Carvalho MM, Panchalingam KM, Rodrigues AJ, Mendes-Pinheiro B, Anjo S, Manadas B, Behie LA, Sousa N, Salgado AJ (2017): Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson’s Disease. Stem Cells Transl Med

Dioli C, Patricio P, Trindade R, Pinto LG, Silva JM, Morais M, Ferreiro E, Borges S, Mateus-Pinheiro A, Rodrigues AJ, Sousa N, Bessa JM, Pinto L, Sotiropoulos I (2017): Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Mol Psychiatry

Caetano L, Pinheiro H, Patricio P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM, Oliveira JF, Ambrosio AF, Sousa N, Cunha RA, Rodrigues AJ, Pinto L, Gomes CA (2017): Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety. Mol Psychiatry

Vyas S, Rodrigues AJ, Silva JM, Tronche F, Almeida OFX, Sousa N, Sotiropoulos I (2016): Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration. Neural Plast

Sotiropoulos I, Silva J, Kimura T, Rodrigues AJ, Costa P, Almeida OFX, Sousa N, Takashima A (2015): Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology. J Alzheimers Dis

Raposo M, Bettencourt C, Maciel P, Gao F, Ramos A, Kazachkova N, Vasconcelos J, Kay T, Rodrigues AJ, Bettencourt B, Bruges-Armas J, Geschwind D, Coppola G, Lima M (2015): Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease. Mov Disord

Pojo M, Goncalves CS, Xavier-Magalhaes A, Oliveira AI, Goncalves T, Correia S, Rodrigues AJ, Costa S, Pinto L, Pinto AA, Lopes JM, Reis RM, Rocha M, Sousa N, Costa BM (2015): A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide. Oncotarget

Morgado P, Marques F, Ribeiro B, Leite-Almeida H, Pego JM, Rodrigues AJ, Dalla C, Kokras N, Sousa N, Cerqueira JJ (2015): Stress induced risk-aversion is reverted by D2/D3 agonist in the rat. Eur Neuropsychopharmacology

Segura-Puimedon M, Sahun I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Perez-Jurado LA, Campuzano V (2014): Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Hum Mol Genet

Patchev AV, Rodrigues AJ, Sousa N, Spengler D, Almeida OFX (2014): The future is now: early life events preset adult behaviour. Acta Physiol

Lopes A, Torres DB, Rodrigues AJ, Cerqueira JJ, Pêgo JM, Sousa N, Gontijo J a. R, Boer PA (2013): Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippocampal neurons but does not alter learning and memory performance in adult offspring. Int J Dev Neurosci

Fraga JS, Silva NA, Lourenco AS, Goncalves V, Neves NM, Reis RL, Rodrigues AJ, Manadas B, Sousa N, Salgado AJ (2013): Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations. Biochimie

Carvalho MM, Campos FL, Coimbra B, Pego JM, Rodrigues C, Lima R, Rodrigues AJ, Sousa N, Salgado AJ (2013): Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits. Mol Neurodegener

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